Israel's military said a projectile launched from Yemen was intercepted before crossing into Israeli territory, but it set off air raid sirens overnight in the country's populous central area, sending residents looking for cover.
Israel’s rescue service Magen David Adom said a 60-year-old woman was seriously wounded after being hurt on her way to a protected space.
There was no immediate comment from Yemen’s Iranian-backed Houthi rebels.
It was the third time in a week that fire from Yemen set off sirens in Israel. On Saturday, a missile slammed into a playground in Tel Aviv, injuring 16, after Israel’s air defense system failed to intercept it.
Earlier last week, Israeli jets struck Yemen’s rebel-held capital and a port city, killing nine. Israel said the strikes were in response to previous Houthi attacks.