Israel is already in a "multifront war" with Iran and its proxies, Israeli Prime Minister Benjamin Netanyahu told a Cabinet meeting Sunday, as the United States and allies prepared to defend Israel from an expected counterstrike and prevent an even more destructive regional conflict.

Tensions have soared following nearly 10 months of war in Gaza and the killing last week of a senior Hezbollah commander in Lebanon and Hamas’ top political leader in Iran. Iran and its allies have blamed Israel and threatened retaliation. Hamas says it has begun discussions on choosing a new leader.

Netanyahu said Israel was ready for any scenario. Jordan's foreign minister was making a rare trip to Iran as part of diplomatic efforts — "We want the escalation to end," Ayman Safadi said — while the Pentagon has moved significant assets to the region.

"We are doing everything possible to make sure that this situation does not boil over," White House deputy national security adviser Jon Finer told ABC. In Israel, some prepared bomb shelters and recalled Iran's unprecedented direct military assault in April following a suspected Israeli strike that killed two Iranian generals. Israel said almost all the drones and ballistic and cruise missiles were intercepted.

A stabbing attack on Sunday near Tel Aviv killed a woman in her 70s and an 80-year-old man, according to Israel's Magen David Adom rescue service and a nearby hospital, and two other men were wounded. The police said the attack was carried out by a Palestinian terrorist, who was "neutralized."

Inside Gaza, Israel’s military said it struck Hamas command centers at two schools in Gaza City, Al-Nasr and Hassan Salamah. A doctor at al-Ahli Hospital, Fadel Naeem, told the AP they had received eight bodies while others were taken to Sheikh Radwan clinic.

Earlier, Israeli strikes killed at least 18 people. One hit a tent camp for thousands of displaced Palestinians in the courtyard of Al-Aqsa Martyrs Hospital, killing four people, including one woman, and injuring others, Gaza's Health Ministry said. An Associated Press journalist filmed men rushing to the scene to retrieve bodies while trying to extinguish the fire.

The Israeli military said it targeted a Palestinian terrorist in the strike, which it said caused secondary explosions, "indicating the presence of weaponry in the area."

The hospital in Deir al-Balah is the main medical facility operating in central Gaza as many others in the territory no longer function. A separate strike on a home near Deir al-Balah killed a girl and her parents, according to the hospital.

Another strike flattened a house in northern Gaza, killing at least eight people, including three children, their parents and their grandmother, according to the Health Ministry. A further three people were killed in a strike on a vehicle in Gaza City, according to the Civil Defense first responders who operate under the Hamas-run government.

Palestinian terrorists in Gaza fired at least five projectiles at Israeli communities near the border without causing casualties or damage, the military said. The military later told people in some parts of the southern Gaza city of Khan Younis to evacuate.

An Israeli strike on Saturday at a school-turned-shelter in Gaza City killed at least 16 people and wounded another 21, according to the Health Ministry, which announced the toll on Sunday. Israel’s military, which regularly accuses Palestinian terrorists of sheltering in civilian areas, said it struck a Hamas command center.

The war in Gaza was triggered by Hamas’ Oct. 7 attack into Israel that killed some 1,200 people, mostly civilians, and took around 250 people hostage.

Israel's massive offensive in response has killed at least 39,580 Palestinians, according to Gaza's Health Ministry, which does not distinguish between civilians and combatants. Heavy airstrikes and ground operations have caused widespread destruction and displaced the vast majority of Gaza's 2.3 million people, often multiple times.

The terrorist group Hezbollah and Israel have continued to trade fire along the Lebanon border since the war began, with the severity growing in recent months. The Lebanese state-run National News Agency said an Israeli strike targeted a house in Beit Lef, and the Lebanese Health Ministry said two people were critically wounded.

Hezbollah says it's aimed at relieving pressure on fellow Iran-backed ally Hamas. A growing number of countries, including the U.S., are encouraging citizens to leave Lebanon after last week's killing of a senior commander.