Dr. Gary Small, M.D.

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Gary Small, M.D., is Chair of Psychiatry at Hackensack University Medical Center, and Physician in Chief for Behavioral Health Services at Hackensack Meridian Health, New Jersey’s largest, most comprehensive and integrated healthcare network. Dr. Small has often appeared on the TODAY show, Good Morning America, and CNN and is co-author (with his wife Gigi Vorgan) of 10 popular books, including New York Times bestseller, “The Memory Bible,” “The Small Guide to Anxiety,” and “The Small Guide to Alzheimer’s Disease.”

Tags: depression | alzheimers ssri | dr. small
OPINION

Antidepressant Can Delay Alzheimer's

Dr. Small By Thursday, 11 September 2025 03:28 PM EDT Current | Bio | Archive

People suffering from depression have a greater risk for developing Alzheimer’s disease. Research shows that the selective serotonin reuptake inhibitor (SSRI) citalopram diminishes abnormal brain amyloid protein associated with the disease.

In The American Journal of Psychiatry, researchers reported on the effect of SSRI treatment on spinal fluid biomarkers and progression of mild cognitive impairment (MCI), which increases risk of cognitive decline that can lead to Alzheimer’s.

Among volunteers with MCI and a history of depression, SSRI treatment for four or more years was associated with a delay in cognitive decline to Alzheimer’s by about three years, compared with subjects who received briefer SSRI treatment, treatment with other antidepressants, or no treatment at all.

© 2025 NewsmaxHealth. All rights reserved.


Dr-Small
Research shows that the selective serotonin reuptake inhibitor (SSRI) citalopram diminishes abnormal brain amyloid protein associated with the disease.
depression, alzheimers ssri, dr. small
114
2025-28-11
Thursday, 11 September 2025 03:28 PM
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