Shortages and the sky-high cost of the new weight-loss drugs have led to an explosion of compounded alternatives sold online, through telehealth sites, and in compounding pharmacies. Unfortunately, most of these products haven't been evaluated by the Food and Drug Administration (FDA) for safety, effectiveness, or quality.

A new study in JAMA found that more than 40% of 317 websites that were selling semaglutide (Wegovy, Ozempic) without a prescription belonged to illegal pharmacy operations. Use of these products can lead to hospitalizations because the medications contain incorrect active ingredients and incorrect dosing.

In addition, an article in JAMA Health Forum reports that when researchers looked at 79 websites selling compounded GLP-1s — usually semaglutide and tirzepatide — 57% didn't say their products were not FDA approved, almost half didn't report the drug's risks (adverse effects, warnings, precautions, and contraindications), and more than 40% overstated benefits.

We're very enthusiastic about the true benefits of FDA-approved weight-loss drugs, including Wegovy, Ozempic, Saxenda, Zepbound. But they're not for everyone and must be combined with lifestyle changes that help you shed pounds and keep them off, including stress management, a diet focused on fresh produce, fatty fish, and 100% whole grains; lots of physical activity, especially strength building; and a posse along with a sense of purpose to help keep you on track.

Only purchase weight-loss medications through FDA-approved outlets. And if you can’t access these medications, don't give up your goal of a healthier weight.