Dr. David Brownstein, M.D
Dr. David Brownstein,  editor of Dr. David Brownstein’s Natural Way to Health newsletter, is a board-certified family physician and one of the nation’s foremost practitioners of holistic medicine. Dr. Brownstein has lectured internationally to physicians and others about his success with natural hormones and nutritional therapies in his practice. His books include Drugs That Don’t Work and Natural Therapies That Do!; Iodine: Why You Need It, Why You Can’t Live Without It; Salt Your Way To Health; The Miracle of Natural Hormones; Overcoming Arthritis, Overcoming Thyroid Disorders; The Guide to a Gluten-Free Diet; and The Guide to Healthy Eating. He is the medical director of the Center for Holistic Medicine in West Bloomfield, Mich., where he lives with his wife, Allison, and their teenage daughters, Hailey and Jessica.

Tags: artificial sweetener | sucralose | inflammation | dr. brownstein
OPINION

Sucralose: Genotoxic Sweetener

David Brownstein, M.D. By Tuesday, 06 May 2025 04:33 PM EDT Current | Bio | Archive

Sucralose, which is marketed as Splenda, is consumed by more than 50 million Americans. It is marketed as “sugar free” and safe for diabetics.

It’s even marketed as a weight-loss agent, but studies have shown that replacing sugar with artificial sweeteners does not achieve significant weight loss.

A study in the Journal of Toxicology and Environmental Health, Part B, looked at the toxicological properties of sucralose, which is metabolized in the intestines. A rodent study found metabolites in fecal samples of rats. A study using a tool that looks for DNA damage found sucralose to be genotoxic — that is, it damages DNA.

The amount of sucralose in a single sucralose-sweetened drink exceeds the threshold for toxicological concern. The scientists also looked at human intestinal epithelia exposed to sucralose and reported that the artificial sweetener, “. . . significantly increased the expression of genes associated with inflammation, oxidative stress, and cancer.” Sucralose was also found to result in leaky gut via an impaired intestinal barrier.

The authors concluded: “Overall, the toxicological and pharmacokinetic findings for sucralose-6-acetate raise significant health concerns regarding the safety and regulatory status of sucralose itself.”

This study is a perfect example of how we have been deceived by corporate America. We were assured that artificial sweeteners are safe, and have been told that diabetics should use artificial sweeteners.

Artificial sweeteners are not safe. Many studies point out safety issues with sucralose. In fact, studies dating back nearly 20 years found sucralose ingestion disrupted microflora in the gut. Rodent studies found that ingestion of sucralose during pregnancy and lactation impacted the progeny’s microbiome.

Sucralose has been found in human breast milk. And as this study pointed out, sucralose is well-known to negatively impact the gastrointestinal tract.

For more than 30 years, I have been writing about the dangers of refined sugar. Artificial sweeteners are not a better choice. It’s best to get your sweets from fruit. If you need to add sugar to something, I suggest using pure organic cane sugar or honey.

More information can be found in my book, The Guide to Healthy Eating.

© 2025 NewsmaxHealth. All rights reserved.


Dr-Brownstein
Sucralose, which is marketed as Splenda, is consumed by more than 50 million Americans. It is marketed as “sugar free” and safe for diabetics.
artificial sweetener, sucralose, inflammation, dr. brownstein
348
2025-33-06
Tuesday, 06 May 2025 04:33 PM
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